ActinomycinDisanantineoplasticantibioticthatinhibitscellproliferationbyactingasacytotoxicinducerofapoptosisagainsttumorcells.
Thisproductisconsideredadangerousgood.Quantitiesabove1gmaybesubjecttoadditionalshippingfees.Pleasecontactusforspecificquestions.
CASNumber
50-76-0
MolecularFormula
C62H86N12O16
MolecularWeight
1255.42
MechanismofAction
Actinomycinisacyclicpolypeptide-containingantibioticthatbindstoDNAandinhibitsRNApolymeraseactivity.BecauseActinomycincanbindDNAduplexes,itcanalsointerferewithDNAreplication,althoughotherchemicalssuchashydroxyureaarebettersuitedforuseinthelaboratoryasinhibitorsofDNAsynthesis.ActinomycinDanditsfluorescentderivative,7-aminoactinomycinD(7-AAD),areusedasstainsinmicroscopyandflowcytometryapplications.Theaffinityofthesestains/compoundsforGC-richregionsofDNAstrandsmakesthemexcellentMarkersforDNA.7-AADbindstosinglestrandedDNA;thereforeitisausefultoolindeterminingapoptosisanddistinguishingbetweendeadandalivecells.
StorageConditions
-20°C
TariffCode
2941.90.1050
