CyclosporinA,EvoPure®isaneutral,cyclicoligopeptidewithimmunosuppressiveactivity.CyclosporinAhasthemostpotentimmunosuppressiveactivityofallthemetabolites(CyclosporinB,C,D,E,andH).CyclosporinAhasbeenusedtopreventorgantransplantrejection.CyclosporinAissolubleinethanol(50mM)andDMSO(100mM).
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CASNumber
59865-13-3
MolecularFormula
C62H111N11O12
MolecularWeight
1202.6g/mol
MechanismofAction
AfterenteringaT-cell,CyclosporinAassociateswiththecytosolicproteincyclophilinwhichhelpsinproteinfolding.CyclosporinAbindstocyclophilinsandthiscomplexbindsanothercytosolicproteinphosphatasecalledCalcineurin(proteinphosphatase2B)thatdephosphorylatesatranscriptionfactor(nuclearfactorofactivatedT-cells,orNF-AT)neededforexpressionofinterleukin2(IL-2.).Italsoblocksthepathwaytonitricoxidesynthesisviatumornecrosisfactor(TNFa)andInterleukin1a.
StorageConditions
-20°C
TariffCode
2933.79.8500