4-Epi-oxytetracycline, EvoPure® (oxytetracycline-related compound A)is an oxytetracycline metabolite and impurity found in commercial oxytetracycline. It can be used as a QC standard during stability studies of oxytetracycline and can be used to study the degradation pathway and products of tetracyclines. 4 -Apo-oxytetracycline, EvoPure® is
We also offer:
- α -Epi-oxytetracycline, EvoPure® (oxytetracycline-related compound A)(O009)
- β -Apo-oxytetracycline, EvoPure® (oxytetracycline-related compound E)(O010)
CAS Number
14206-58-7
Molecular Formula
C22H24N2O9
Molecular Weight
460.43
Mechanism of Action
Oxytetracycline causes inhibition of protein synthesis. It binds to the 30S ribosomal subunit and prevents the amino-acyl tRNA from binding to the A site of the ribosome.In an acellular model systems of protein synthesis using ribosomes from tetracycline sensitive and resistant strains of E. coli in the synthesis of polyphenylalanine, oxytetracycline showed inhibitory activity along with minocycline. 4-Epi-oxytetracycline and beta-apo-oxytetracycline had competing properties with respect to oxytetracycline at the stage of penetration through the cell membrane but did not, however, suppress the synthesis of polyphenylalanine.
Storage Conditions
-20 °C
Tariff Code
2941.30.0000
Spectrum
4-epi-oxytetracycline has only 5% of the potency againstStaphylococcus aureusandE. colicompared to oxytetracycline. 4-epi-oxytetracycline can also be used to prepareS. aureusandE. coliselective media.
