Ceftazidime,Delta-3-Isomer,EvoPure®isanisomeranddegradationproductofCeftazidime.ItcanbeusedasareferencestandardtotraceCeftazidime.ThisisomerwasformerlyknownasDelta-2.
Ceftazidimeisabroad-spectrum,third-generation,β-lactamcephalosporinthatinterfereswithbacterialcellwallsynthesis.Patentedin1979byGlaxoGroup,Ceftazidimecameintocommercialusein1984.Itissparinglysolubleinaqueoussolution.
EvoPure®productsarehighlypurifiedcompoundsthatcanbeusedforinvitroapplicationslikeanalyticalreferencestandards,upstreampharmaceuticalproductmanufacturing,geneselection,andtoxicitystudies.
ForadditionalEvoPure®products,clickhere.
CASNumber
NotEstablished
MolecularFormula
C22H22N6O7S2·5H2O
MolecularWeight
636.65
MechanismofAction
Likeβ-lactams,cephalosporinsinterferewithPBP(penicillinbindingprotein)activityinvolvedinthefinalphaseofpeptidoglycansynthesis.PBP’sareenzymeswhichcatalyzeapentaglycinecrosslinkbetweenalanineandlysineresiduesprovidingadditionalstrengthtothecellwall.Withoutapentaglycinecrosslink,theintegrityofthecellwallisseverelycompromisedandultimatelyleadstocelllysisanddeath.Resistancetocephalosporinsiscommonlyduetocellscontainingplasmid-encodedβ-lactamases,however,Ceftazidimeisstableinthepresenceofβ-lactamases.
StorageConditions
-20°C
TariffCode
2941.90.3000
Spectrum
Ceftazidimeisbroad-spectrum,targetingbothGram-negativeandGram-positivebacteria,butismosteffectiveforGram-negativestrainsincludingPseudomonasaeruginosaandEnterobacteriaceae(includingβ-lactamasepositivestrains).ItisalsousedforagainstStreptococcuspneumoniae,andS.pyogenes.
