Amphotericin B, Solubilized is a solubilized form of Amphotericin B, a polyene antibiotic used used to control contamination from fungi, viruses, and protozoa.Amphotericin B is derived fromStreptomyces nodosusand is nearly insoluble in water in its standard form. The addition of sodium deoxycholate is required in order to maximize the solubility.

TOKU-E offers three forms of Amphotericin B:

• Amphotericin B, Solubilized (A008)
• Amphotericin B, USP (A007)
• Amphotericin B, EP (A064)

CAS Number

1397-89-3 (Amphotericin B)

Molecular Formula

C₄₇H₇₃NO₁₇ (Amphotericin B)

Molecular Weight

924.08 (Amphotericin B)

Mechanism of Action

Amphotericin B associates with membrane sterols (ergosterol in fungal cell membranes, and cholesterol in mammalian cell membranes). Amphotericin B forms a pore in these membranes resulting in leakage of essential ions and ultimately cell death.

Storage Conditions

2-8°C

Tariff Code

2941.20.5000

Spectrum

Amphotericin B is active against mammalian cells, fungi, viruses, and protozoa. Amphotericin B is not toxic to bacteria due to their lack of sterols..

The following represents MIC susceptibility data for amphotericin B against common fungal pathogens:

• Candida albicans- 0.001 - 321 μg/mL
• Candida krusei- 0.001 - 16 μg/mL
• Coccidioides immitis- 0.0625 - 2 μg/mL
• Cryptococcus neoformans- 0.2 - 39 μg/mL
• Fusarium oxysporum- 0.75 - 125 μg/mL