Chloramphenicol acetate is the major product of chloramphenicol acetyltransferase, and is a natural co-metabolite of chloramphenicol with lower potency. It is broad-spectrum, effective against a wide variety of Gram-positive and Gram-negative bacteria.

Chloramphenicol acetate is soluble inethanol, methanol, DMF and DMSO.

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CAS Number

10318-16-8

Molecular Formula

C₁₃H₁₄Cl₂N₂O₆

Molecular Weight

365.2

Mechanism of Action

After entering a bacterial cell, Chloramphenicol reversibly binds to the peptidyltransferase center at the 50S ribosomal subunit of 70S ribosome, preventing peptide bond formation. Resistance to Chloramphenicol may be due to decreased cell permeability or a mutation in the 50S ribosomal subunit.

Storage Conditions

-20°C

Spectrum

Chloramphenicol is effective against Gram-positive and Gram-negative bacteria, both aerobic and anaerobic bacteria.It is also effective against Mycoplasmas, Chlamydiae, and Rickettsiae.