Amphotericin B, USP is a polyene antifungal or antimycotic compound derived fromStreptomyces nodosus. It is used to control contamination from fungi, viruses and protozoa.

TOKU-E offers 3 forms of Amphotericin B:

• Amphotericin B, USP (A007)
• Amphotericin B, EP (A064)
• Amphotericin B, solubilized (A008)

The compound is nearly insoluble in water at pH 6-7 (but is soluble at pH 2 or 11). It is soluble in dimethyl sulfoxide and dimethylformamide.

Amphotericin B, USP conforms to United States Pharmacopoeia specifications.

CAS Number

1397-89-3

Molecular Formula

C₄₇H₇₃NO₁₇

Molecular Weight

924.08

Mechanism of Action

Amphotericin B associates with membrane sterols (ergosterol in fungal cell membranes, and cholesterol in mammalian cell membranes). Amphotericin B forms a pore in these membranes resulting in leakage of essential ions and ultimately cell death.

Storage Conditions

2-8°C

Tariff Code

2941.90.1050

Spectrum

Amphotericin B is active against mammalian cells, fungi, viruses, and protozoa.Amphotericin B is not toxic to bacteria due to their lack of sterols.

The following represents MIC susceptibility data for amphotericin B against common fungal pathogens:

• Candida albicans- 0.001 - 321 μg/mL
• Candida krusei- 0.001 - 16 μg/mL
• Coccidioides immitis- 0.0625 - 2 μg/mL
• Cryptococcus neoformans- 0.2 - 39 μg/mL
• Fusarium oxysporum- 0.75 - 125 μg/mL