Gentamicin Sulfate, EP is an aminoglycoside antibiotic complex discovered in 1963 derived from fermentation ofMicromonospora purpureaorM. echinospora.Gentamicin is composed of different components including Gentamicin C complex (gentamicin C1,gentamicin C1a, andgentamicin C2) which makes up 80% of the compound and has the highest antibacterial activity, along with Gentamicin A, B, X, and a few others which make up the remaining 20% of Gentamicin and have lower antibiotic activity.Gentamicin Sulfate is suitable for use in cell culture to prevent and control bacterial contamination and the compound is soluble in water (50 mg/ml).

Gentamicin Sulfate, EP conforms to European Pharmacopoeia specifications.

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CAS Number

1405-41-0

Molecular Formula

C₂₁H₄₃N₅O₇ • H₂SO₄

Molecular Weight

575.67 g/mol

Mechanism of Action

Aminoglycosides are a widespread and versatile group of bioactive natural products.They target the 30S ribosomal subunit, blocking the translocation of peptidyl-tRNA from acceptor to donor.This results in an inability to read mRNA ultimately producing a faulty or nonexistent protein.

Tariff Code

2941.90.1010

Spectrum

Gentamicin Sulfate, EP is a broad-spectrum antibiotic targeting Gram-positive and Gram-negative bacteria. It is effective against several strains of Mycoplasma.It also combats certain β-lactam sensitive VRE or vancomycin resistant Enterococcus; a "superbug."