Source
Bacilluspolymyxavar.colistinus
PolymyxinE2sulfateorcolistinB isoneofthetwomajorcomponentsofpolymyxinE(colistin). PolymyxinE1andE2arestructurallysimilaranddifferonlybyafattyacidgroupattheN-terminus.PolymyxinE1contains6-methyloctanoicacidandpolymyxinE2(colistinB)contains6-methylheptanoicacid.Together,polymyxinE1andE2compriseapproximately85%ofpolymyxinE;however,13differentpolymyxinEcomponentshavebeenindentified.
7239-48-7(freebase)
C52H98N16O13·xH2SO4(lotspecific)
1155.43(Freebase)
PolymyxinEhasabactericidaleffectonGramnegativebacteriabyinteractingwithanddisplacingessentialionsinthelipopolysaccharide(LPS)outercellwallleADIngtoincreasedpermeABIlityandeventuallylysisanddeathofthecell.
-20°C
2941.90.1050
PolymyxinEisusedprimarilyagainstGramnegativebacteriaincludingPseudomonasaeruginosa,Klebsiellapneumoniae,andmulti-drugresistantEnterobacteriaceae,
Bacilluspolymyxavar.colistinus