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Bacilluspolymyxavar.colistinus
PolymyxinE1sulfateorcolistinAisoneofthetwomajorcomponentsofpolymyxinE(colistin). PolymyxinE1andE2arestructurallysimilaranddifferonlybyafattyacidgroupattheN-terminus.PolymyxinE1contains6-methyloctanoicacidandpolymyxinE2(colistinB)contains6-methylheptanoicacid.Together,polymyxinE1andE2compriseapproximately85%ofpolymyxinE;however,13differentpolymyxinEcomponentshavebeenindentified.
7722-44-3(freebase)
C53H100N16O13·xH2SO4 (lotspecific)
1169.46g/mol(Freebase)
PolymyxinEhasabactericidaleffectonGramnegativebacteriabyinteractingwithanddisplacingessentialionsinthelipopolysaccharide(LPS)outercellwallleADIngtoincreasedpermeABIlityandeventuallylysisanddeathofthecell.
-20°C
2941.90.1050
PolymyxinEisusedprimarilyagainstGramnegativebacteriaincludingPseudomonasaeruginosa,Klebsiellapneumoniae,andmulti-drugresistantEnterobacteriaceae,
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Bacilluspolymyxavar.colistinus