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Pseudomonassp.
PolymyxinB1sulfateisoneofthepolypeptidefractionsinpolymyxinBsulfate.ThefattyacidgroupfoundinpolymyxinB1sulfateis6-methyloctanoicacid(6-MOA);thesamegroupfoundinpolymyxinB1-Isulfate.PolymyxinB1however,containsaL-leucineresidue,ratherthantheL-isoleucineresidefoundinpolymyxinB1-Isulfate.Resultsfrom invitro studieshaveshownmarginaldifferencesinMICdatawhencomparingthefractions.
Kassamali,etal. used polymyxinB1, polymyxinB2, polymyxin B3,and polymyxin B1-I totestforsynergisticandantagoNISTiceffectsagainstvariousGram-negativeorganisms.
Readmorehere:"MicroBIOLOGicalAssessmentofPolymyxinBComponentsTestedAloneandInCombination"
Limetal. usedpolymyxin B1,B2,B3,andB1-IfromTOKU-EtostudythestABIlityofeachcompoundinsaline,dextrose,andsaline/dextroseinfusionsolutions. "PhysicochemicalstabilitystudyofpolymyxinBinvariousinfusionsolutionsforadministrationtocriticallyIllpatients."
4135-11-09
C56H98N16O13·xH2SO4 (lotspecific)
1203.47g/mol(Freebase)
PolymyxinBtargetsandalterspermeabilitylipopolysaccharide(LPS)ofgramnegativebacterialeADIngtolysingofthecell.PolymyxinBonlyneedstointeractwithLPS,itisnotrequiredtoenterthecell.
-20°C
2941.90.1050
PolymyxinBsulfatetargetstheoutermembraneofgramnegativebacteriaespeciallyPseudomonasaeruginosa.
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Pseudomonassp.