Form
Powder
Appearance
Whiteoroff-whitecrystallinepowder
Source
Streptomycesverticillus
pH
4.5-6.0
LossonDrying
≤6.0%
HeavyMetals
Copper:≤0.1%
BleomycinsulfateisawatersolubleanticancerchemotherapeuticagentcommonlyusedtotreatHodgkin’slymphoma. Bleomycincomprisesamixtureoftwocomponents:bleomycinA2andbleomycinB2.TheapproximatecompositionofA2:B2is2:1;however,theratiocanvarygreatlydependingonthelottested.
TOKU-Eoffersthreeformsofbleomycin:bleomycinsulfate(B005),bleomycinA2sulfate,EvoPure®(B019),andbleomycinB2sulfate,EvoPure®(B020).EvoPure®productsareindividualmolecularfractions,most>99%pure.
9041-93-4
BleomycinactsasananticanceragentbycausingsinglestrandedbreaksinDNA.Theexactmechanismisnotwelldefinedhowever;itisthoughttochelatemetallicionstodecreaseenzymeactivityandstABIlity.ThiseffectisbelievedtocauseenzymestoreactwithoxygenproducingfreerADIcalswhichcreatesinglestrandedbreaksindeoxyribosesugar.
2-8°C
2941.90.5000
Powder
Whiteoroff-whitecrystallinepowder
Streptomycesverticillus
4.5-6.0
≤6.0%
Copper:≤0.1%