Form
Powder
Appearance
Violetbluecrystal
Source
StreptomycesCaespitosus
WaterContent(KarlFisher)
≤2.5%
Potency(onadrybasis)
≥970µg/mg
pH
6.0-7.5
MeltingPoint
360°C
MitomycinCisabacteriocidalmethylazirinopyrroloindoledioneantineoplasticantibioticisolatedStreptomycesspp.
50-07-7
C15H18N4O5
334.33
MitomycinCisactivatedbyreductioninvivogeneratingoxygenrADIcalswhichproducecrosslinksinDNAbyalkylation.ThismechanismultimatelyinhibitsDNAsynthesiswhichhasabacteriostaticeffect.
2-8°C
2941.90.1050
Powder
Violetbluecrystal
StreptomycesCaespitosus
≤2.5%
≥970µg/mg
6.0-7.5
360°C