Form
Powder
Appearance
White crystalline powder
Source
Semi-synthetic
pH
2.0 - 4.0
Optical Rotation
+76° to +84°
Assay
(On Dried Basis): 674-786 µg/mg
Loss on Drying
≤13.0%
Residue On Ignition
≤1.0%
Amikacin sulfate is broad spectrum aminoglycoside antibiotic derived from its counterpart kanamycin A. Amikacin sulfate (A003) contains a amikacin:sulfate ratio of 1:2.
TOKU-E offers three forms of amikacin: amikacin hydrate (A002), amikacin sulfate (1:2) (A003), and amikacin sulfate (1:1.8) (A070). All forms have similar potencies and are freely soluble in aqueous solution (50 mg/mL).
39831-55-5
C22H43N5O13 •2H2SO4
781.76
Similar to other aminoglycosides, amikacin sulfate binds to the 30S ribosomal subunit resulting in an inability to read mRNA ultimately producing a faulty or nonexistent protein.
2-8°C
2941.90.5000
Species susceptible to amikacin include gram negative bacteria such as Pseudomonas aeruginosa and several key enteric species. In addition, certain non-gram negative species including Mycobacterium tuberculosis have also demonstrated susceptibility to amikacin.
Powder
White crystalline powder
Semi-synthetic
2.0 - 4.0
+76° to +84°
(On Dried Basis): 674-786 µg/mg
≤13.0%
≤1.0%