Form
Powder
Appearance
Whitecrystallinepowder
Source
Semi-synthetic
pH
2.0-4.0
OpticalRotation
+76°to+84°
Assay
(OnDriedBasis):674-786µg/mg
LossonDrying
≤13.0%
ResidueOnIgnition
≤1.0%
AmikacinsulfateisbroadspectrumaminoglycosideantibioticderivedfromitscounterpartkanamycinA. Amikacinsulfate(A003)containsaamikacin:sulfateratioof1:2.
TOKU-Eoffersthreeformsofamikacin:amikacinhydrate(A002),amikacinsulfate(1:2)(A003),andamikacinsulfate(1:1.8)(A070).Allformshavesimilarpotenciesandarefreelysolubleinaqueoussolution(50mg/mL).
39831-55-5
C22H43N5O13•2H2SO4
781.76
Similartootheraminoglycosides,amikacinsulfatebindstothe30SribosomalsubunitresultinginaninABIlitytoreadmRNAultimatelyproducingafaultyornonexistentprotein.
2-8°C
2941.90.5000
SpeciessusceptIBLetoamikacinincludegramnegativebacteriasuchasPseudomonasaeruginosaandseveralkeyentericspecies.Inaddition,certainnon-gramnegativespeciesincludingMycobacteriumtuberculosishavealsodemonstratedsusceptibilitytoamikacin.
Powder
Whitecrystallinepowder
Semi-synthetic
2.0-4.0
+76°to+84°
(OnDriedBasis):674-786µg/mg
≤13.0%
≤1.0%