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Likeβ-lactams,cephalosporinsinterferewithPBP(penicillinbindingprotein)activityinvolvedinthefinalphaseofpeptidoglycansynthesis.PBP’sareenzymeswhichcatalyzeapentaglycinecrosslinkbetweenalanineandlysineresiduesprovidingadditionalstrengthtothecellwall.Withoutapentaglycinecrosslink,theintegrityofthecellwallisseverelycompromisedandultimatelyleadstocelllysisanddeath.Resistancetocephalosporinsiscommonlyduetocellscontainingplasmidencodedβ-lactamases,however,ceftazidimeisstableinthepresenceofβ-lactamases.
CeftazidimepentahydratetargetsprimarilygramnegativebacteriaespeciallyPseudomonasaeruginosaunlikeotherthirdgenerationcephalosporins.
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