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Pseudomonassp.
PolymyxinB2sulfateisoneofseveralpolypeptidecomponentsthatcomprisestheantibioticpolymyxinBsulfate.TheuniquefattyacidmoietyfoundinpolymyxinB2is6-methylheptanoicacid(6-MHA).Resultsfrom invitro studieshaveshownmarginaldifferencesinMICdatawhencomparingthefractions.
Kassamali,etal. used polymyxinB1, polymyxinB2, polymyxin B3,and polymyxin B1-I totestforsynergisticandantagoNISTiceffectsagainstvariousGram-negativeorganisms.
Readmorehere:"MicroBIOLOGicalAssessmentofPolymyxinBComponentsTestedAloneandInCombination"
Limetal. usedpolymyxin B1,B2,B3,andB1-IfromTOKU-EtostudythestABIlityofeachcompoundinsaline,dextrose,andsaline/dextroseinfusionsolutions. "PhysicochemicalstabilitystudyofpolymyxinBinvariousinfusionsolutionsforadministrationtocriticallyIllpatients."
N/A
C55H96N16O13·xH2SO4(lotspecific)
1189.45g/mol(Freebase)
PolymyxinBtargetsandalterspermeabilitylipopolysaccharide(LPS)ofgramnegativebacterialeADIngtolysingofthecell.PolymyxinBonlyneedstointeractwithLPS,itisnotrequiredtoenterthecell.
-20°C
2941.90.1050
PolymyxinBsulfatetargetstheoutermembraneofgramnegativebacteriaespeciallyPseudomonasaeruginosa.
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Pseudomonassp.