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BacillusPolymyxa
PolymyxinBsulfateisapolypeptideantibioticandiscomposedofpolymyxinsB1,B2,andB3withfractionsB1andB2comprisingthemajorityofthemixture.PolymyxinB6sulfateisfreelysolubleinaqueoussolution(25mg/mL). PolymyxinBcomponentsarestructurallyidenticalwiththeexceptionofavariablefattyacidgrouponeachfraction.ResultsfrominvitrostudieshaveshownmarginaldifferencesinMICdatawhencomparingthefractions.
TOKU-EofferssixformsofpolymyxinBsulfate:polymyxinBsulfate(P007),polymyxinB1sulfate,EvoPure®(P037),polymyxinB1-Isulfate,EvoPure®(P038),polymyxinB2sulfate,EvoPure®(P039), polymyxinB3sulfate,EvoPure®(P040),andpolymyxinB6sulfate,EvoPure®. EvoPure®productsarepurifiedsingleantibioticfractions,most>99%pure.HighpurityEvoPure®polymyxinproductscanbeusedtoanalyzethespecifceffectsofindividualpolymyxinBfractions.
C56H98N16O14•xH2SO4(lotspecific)
1219.47(Freebase)
PolymyxinBtargetsandalterspermeABIlitylipopolysaccharide(LPS)ofgramnegativebacterialeADIngtolysingofthecell.PolymyxinBonlyneedstointeractwithLPS,itisnotrequiredtoenterthecell.
2941.90.1050
PolymyxinBsulfatetargetstheoutermembraneofgramnegativebacteriaespeciallyPseudomonasaeruginosa.
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BacillusPolymyxa