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Pseudomonassp.
PolymyxinB3sulfateisanindividualfractionfoundintheantibioticmixturepolymyxinBsulfate.PolymyxinB3sulfateisdifferentiatedfromitscounterpartfractionsbythepresenceofanoctanoicfattyacidmoiety.Resultsfrom invitro studieshaveshownmarginaldifferencesinMICdatawhencomparingthefractions.
Kassamali,etal. used polymyxinB1, polymyxinB2, polymyxin B3,and polymyxin B1-I totestforsynergisticandantagoNISTiceffectsagainstvariousGram-negativeorganisms.
Readmorehere:"MicroBIOLOGicalAssessmentofPolymyxinBComponentsTestedAloneandInCombination"
Limetal. usedpolymyxin B1,B2,B3,andB1-IfromTOKU-EtostudythestABIlityofeachcompoundinsaline,dextrose,andsaline/dextroseinfusionsolutions. "PhysicochemicalstabilitystudyofpolymyxinBinvariousinfusionsolutionsforadministrationtocriticallyIllpatients."
C55H96N16O13·xH2O4S(lotspecific)
1189.45g/mol(Freebase)
PolymyxinBtargetsandalterspermeabilitylipopolysaccharide(LPS)ofgramnegativebacterialeADIngtolysingofthecell.PolymyxinBonlyneedstointeractwithLPS,itisnotrequiredtoenterthecell.
-20°C
2941.90.1050
PolymyxinBsulfatetargetstheoutermembraneofgramnegativebacteriaespeciallyPseudomonasaeruginosa.
Kassamali,etal.foundpolymyxinB3tobethemostactivepolymyxinfractionagainstmostorganismsintheirexperiment.Kassamali,etal.alsodiscoveredasynergisticeffectusingpolymyxinB3andB1-Iagainsttheirtestedorganisms.
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Pseudomonassp.