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DemethylbleomycinA2sulfate,EvoPure® (bleomycinimpurityD)isademethylatedformofbleomycinA2- amajorcomponentinstandardgradebleomycin.DemethylbleomycinA2isformedbyheatingbleomycinA2.DemethylbleomycinA2comprisesapproximately3.0%ofstandardgradebleomycin.DemethylbleomycinA2hasbeenfoundtohavehighantimicrobialactivityagainstMycobacteriumsmegmatiscomparedtobleomycinA2.Additionally,demethylbleomycinA2hasalowertoxicityprofileandgreaterantitumorpropertiesthanbleomycinA2.
C54H81N17O21S3·xH2SO4
1400.51(Freebase)
2941.90.1010
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