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BacillussubtilisvarTracy ≥95%(HPLC)Assay
Bacitraciniscomprisedofnumerousantimicrobialpeptidefractions.NotablefractionsincludeA,A1,B,B1,B2,C,D,E,F,G,andX.Standardgradebacitracin(B002)isamixtureofthesefractions.BacitracinAisthemostactiveandpotentpeptidefractioninbacitracinandisverysimilartoitsbacitracinBcounterpart.
Formorebacitracinproducts,includingfractions, clickhere.
Webbetal. usedBacitracinF,EvoPuretostudyitseffectonproteindisulfideisomerase(PDI)inhibition.Readmorehere: Dose-ResponseModelsRevealCriticalFeaturesofInhibitorActivityandViralInfection.
Watermanetal.usedbacitracinF,EvoPure fromTOKU-Easareferencestandardtoconfirmtheformationofthedegradantproduct,bacitracinFfromtheactive,bacitracinA.Readmorehere:"AcceleratedStABIlityModelingforPeptides:aCaseStudywithBacitracin."
22601-63-4
C66H98N16O17S
1419.65g/mol
Bacitracinpreventsphosphorylationofbactoprenol;atransportproteinwhichcarriespeptidoglycancomponentsoutsidethecellmembrane.Withouttheactivephosphorylatedbactoprenol,peptidoglycansynthesiscannotbecompleteandthecelllyses.Twomechanismsofbacitracinresistanceareunderstood.OnemechanismreliesonaproteincalledaBcrABCtransporterwhichpumpsbacitracinoutafterithasenteredthecell.AnalternativemechanismisduetoanotherproteincalledBacAwhichprovidestheactivephosphorylatedbactoprenolfromadifferentsyntheticpathway.
-20°C
2941.90.5000
BacitracinprimarilytargetsthecellwallinmembersofthegrampositivebacteriaincludingStreptococcuspyogenesandStaphylococcusaureus.
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BacillussubtilisvarTracy ≥95%(HPLC)Assay