Form
EvoPure®Powder
Appearance
Whiteoroff-whitepowder
Source
Bacillussubtilus
Assay
≥95%(HPLC)
Bacitraciniscomprisedofnumerousantimicrobialpeptidefractions.NotablefractionsincludeA,A1,B,B1,B2,C,D,E,F,G,andX.Standardgradebacitracin(B002)isamixtureofthesefractions.BacitracinAisthemostactiveandpotentpeptidefractioninbacitracinandisverysimilartoitsbacitracinBcounterpart.
Formorebacitracinproducts,includingfractions,clickhere.
Webbetal.usedBacitracinA,EvoPuretostudyitseffectonproteindisulfideisomerase(PDI)inhibition.Readmorehere:Dose-ResponseModelsRevealCriticalFeaturesofInhibitorActivityandViralInfection.
22601-59-8
C66H103N17O16S
1422.71
Bacitracinpreventsphosphorylationofbactoprenol;atransportproteinwhichcarriespeptidoglycancomponentsoutsidethecellmembrane.Withouttheactivephosphorylatedbactoprenol,peptidoglycansynthesiscannotbecompleteandthecelllyses.Twomechanismsofbacitracinresistanceareunderstood.OnemechanismreliesonaproteincalledaBcrABCtransporterwhichpumpsbacitracinoutafterithasenteredthecell.AnalternativemechanismisduetoanotherproteincalledBacAwhichprovidestheactivephosphorylatedbactoprenolfromadifferentsyntheticpathway.
-20°C
2941.90.5000
BacitracinprimarilytargetsthecellwallinmembersofthegrampositivebacteriaincludingStreptococcuspyogenesandStaphylococcusaureus.
EvoPure®Powder
Whiteoroff-whitepowder
Bacillussubtilus
≥95%(HPLC)