Form
Powder
Appearance
Yellowororangepowder
Source
Streptomycesnodosus
Assay
(AsIs):≥240µg/mg
Impurities
Mycoplasma:Nonedetected
Endotoxin
≤40EU/mg
AmphotericinB,solublizedisasolubilizedformofthepolyeneantifungalorantimycotic,amphotericinB.AmphotericinBisa polyeneantifungalorantimycoticcompoundderivedfrom Streptomycesnodosus.
StandardpowderamphotericinBisnearlyinsolubleinwaterandrequirestheadditionofsodiumdeoxycholatetomaximizesolubility.
1397-89-3(AmphotericinB)
C47H73NO17(AmphotericinB)
924.08(AmphotericinB)
AmphotericinBassociateswithmembranesterolsinmammalianandfungalcellmembranes.AmphotericinBformsaporeinthesemembranesleADIngtoessentialionleakageandultimately,celldeath.
2-8°C
2941.20.5000
AmphotericinBisactiveagainstmammalianandfungal(moldsandyeasts)cells.AmphotericinBisnottoxictobacteriaduetotheirlackofsterols. ThefollowingrepresentsMICsusceptibilitydataforamphotericinBagainstcommonfungalpathogens:
Powder
Yellowororangepowder
Streptomycesnodosus
(AsIs):≥240µg/mg
Mycoplasma:Nonedetected
≤40EU/mg