Form
Powder
Appearance
Yellowororangepowder
Source
Streptomycesnodosus
WaterContent(KarlFisher)
≤5.0%
Assay
(OnDriedBasis)L:≥750µg/mg
LossonDrying
≤5.0%
ResidueOnIgnition
≤0.5%
Impurities
AmphotericinA:≤15.0%
Endotoxin
≤0.9EU/mg
AmphotericinB,USPisapolyeneantifungalorantimycoticcompoundderivedfrom Streptomycesnodosus.AmphotericinBisnearlyinsolubleinwaterbutcanbesolubilizedinsodiumdeoxycholate.
AmphotericinB,USPmeetsUnitedStatesPharmacopoeiaspecifications.
1397-89-3
C47H73NO17
924.08
AmphotericinBassociateswithmembranesterolsinmammalianandfungalcellmembranes.AmphotericinBformsaporeinthesemembranesleADIngtoessentialionleakageandultimately,celldeath.
2-8°C
2941.90.1050
AmphotericinBisactiveagainstmammalianandfungal(moldsandyeasts)cells.AmphotericinBisnottoxictobacteriaduetotheirlackofsterols. ThefollowingrepresentsMICsusceptibilitydataforamphotericinBagainstcommonfungalpathogens:
Powder
Yellowororangepowder
Streptomycesnodosus
≤5.0%
(OnDriedBasis)L:≥750µg/mg
≤5.0%
≤0.5%
AmphotericinA:≤15.0%
≤0.9EU/mg