Form
Powder
Appearance
White or yellowish powder
Source
Streptomyces Fradiae.
Elemental Analysis
Sulphate: 27.0-31.0%
Impurity Profile
Impurity A| 2-deoxy-4-O-(2,6-diamino-2,6-dideoxy-d-glucopyranosyl)-d-streptamine (neamine or neomycin A-LP)|||| Impurity B| 3-N-acetyl-2-deoxy-4-O-(2,6-diamino-2,6-dideoxy-d-glucopyranosyl)-d-streptamine (3-acetylneamine)|||| Impurity C| 4-O-(2-amino-2-deoxy-d-glucopyranosyl)-2-deoxy-d-streptamine (paromamine or neomycin D)|||| Impurity D| 2-deoxy-4-O-(2,6-diamino-2,6-dideoxy-d-glucopyranosyl)-5-O-[3-O-(2,6-diamino-2,6-dideoxy-d-glucopyranosyl)-d-ribofuranosyl]-d-streptamine (neomycin C)|||| Impurity E| 4-O-(2-amino-2-deoxy-d-glucopyranosyl)-2-deoxy-5-O-[3-O-(2,6-diamino-2,6-dideoxy-l-idopyranosyl)-d-ribofuranosyl]-d-streptamine (paromomycin I or neomycin E)|||| Impurity F| 4-O-(2-amino-2-deoxy-d-glucopyranosyl)-2-deoxy-5-O-[3-O-(2,6-diamino-2,6-dideoxy-d-glucopyranosyl)-d-ribofuranosyl]-d-streptamine (paromomycin II or neomycin F)|||| Impurity G| 3-N-acetyl-2-deoxy-4-O-(2,6-diamino-2,6-dideoxy-d-glucopyranosyl)-5-O-[3-O-(2,6-diamino-2,6-dideoxy-l-idopyranosyl)-d-ribofuranosyl]-d-streptamine (neomycin B-LP)||||
pH
5.0-7.5
Optical Rotation
+53.5° to +59.4°
Assay
(Dried Basis): ≥680IU/mg
Loss on Drying
≤8.0%
