Form
Powder
Appearance
Whiteoralmostwhitecrystallinepowder
Source
Penicilliumsp.
pH
5.0-7.5
MeltingPoint
214-217°C
Assay
(OnDriedBasis):1440-1680u/mg
LossonDrying
Notmorethan1.5%
Penicillinisamemberoftheβ-lactamantibioticsandwasoneofthefirstdiscoveredantibiotics.
PenicillinGpotassiumissparinglysolubleinaqueoussolution(0.210mg/mL).Clickhereformoreformsofpenicillin.
113-98-4
C16H17KN2O4S
372.49
β-lactamsinterferewithPBP(penicillinbindingprotein)activityinvolvedinthefinalphaseofpeptidoglycansynthesis.PBP’sareenzymeswhichcatalyzeapentaglycinecrosslinkbetweenalanineandlysineresiduesprovidingadditionalstrengthtothecellwall.Withoutapentaglycinecrosslink,theintegrityofthecellwallisseverelycompromisedandultimatelyleadstocelllysisanddeath.Resistancetoβ-lactamsiscommonlyduetocellscontainingplasmidencodedβ-lactamases.
2-8°C
2941.10.2000
PenicillinistargetsprimarilygrampositivebacteriaincludingStaphylococcusandStreptococcusspecies.
Powder
Whiteoralmostwhitecrystallinepowder
Penicilliumsp.
5.0-7.5
214-217°C
(OnDriedBasis):1440-1680u/mg
Notmorethan1.5%