Polymyxin B sulfate is a polypeptide antibiotic and is composed of polymyxins B1, B2, and B3 with fractions B1 and B2 comprising the majority of the mixture. Polymyxin B sulfate is freely soluble in aqueous solution (25 mg/mL). Polymyxin B components are structurally identical with the exception of a variable fatty acid group on each fraction. Results from in vitro studies have shown marginal differences in MIC data when comparing the fractions.

TOKU-E offers six forms of polymyxin B sulfate: polymyxin B sulfate (P007), polymyxin B1 sulfate, EvoPure® (P037), polymyxin B1-I sulfate, EvoPure® (P038), polymyxin B2 sulfate, EvoPure® (P039), polymyxin B3 sulfate, EvoPure® (P040), and polymyxin B6 sulfate, EvoPure®. EvoPure® products are purified single antibiotic fractions, most >99% pure. High purity EvoPure® polymyxin products can be used to analyze the specifc effects of individual polymyxin B fractions.

CAS Number

1405-20-5

Molecular Formula

Mixture

Molecular Weight

1385.61

Mechanism of Action

Polymyxin B targets and alters the permeability of lipopolysaccharide (LPS) found in Gram negative bacteria leading to lysing of the cell. Polymyxin B only needs to interact with LPS, it is not required to enter the cell.

Storage Conditions

2-8°C

Tariff Code

2941.90.1050

Spectrum

Polymyxin B sulfate targets the outer membrane of gram negative bacteria especially Pseudomonas aeruginosa.

Specifications: