PolymyxinBsulfateisapolypeptideantibioticandiscomposedofpolymyxinsB1,B2,andB3withfractionsB1andB2comprisingthemajorityofthemixture.PolymyxinBsulfateisfreelysolubleinaqueoussolution(25mg/mL). PolymyxinBcomponentsarestructurallyidenticalwiththeexceptionofavariablefattyacidgrouponeachfraction.ResultsfrominvitrostudieshaveshownmarginaldifferencesinMICdatawhencomparingthefractions.
CASNumber
1405-20-5
MolecularFormula
Mixture
MolecularWeight
1385.61
MechanismofAction
PolymyxinBtargetsandaltersthepermeABIlityoflipopolysaccharide(LPS)foundinGramnegativebacterialeADIngtolysingofthecell.PolymyxinBonlyneedstointeractwithLPS,itisnotrequiredtoenterthecell.
StorageConditions
2-8°C
TariffCode
2941.90.1050
Spectrum
PolymyxinBsulfatetargetstheoutermembraneofgramnegativebacteriaespeciallyPseudomonasaeruginosa.
Form
Powder
Appearance
Whitepowder
Source
BacillusPolymyxa
ImpurityProfile
PolymyxinB1||4135-11-9|C56H98N16O13|1204|PolymyxinB2|||C55H96N16O13|1190|PolymyxinB3|||C55H96N16O13|1190|PolymyxinB1-I|||C56H98N16O13|1204|
MeltingPoint
217-220°C
Assay
(DriedBasis):≥6,000u/mg
LossonDrying
≤7.0%