PuromycinisanucleosideantibioticisolatedfromStreptomycesalbonigerinthe1950sasananti-trypanosomalagentwithantibioticactivity.Puromycinisusedincell
ytoselectmammaliancelllinesthathavebeentransformedbyvectorsthatexpresspuromycin-N-acetyl-transferase.
Puromycinissolublein ethanol,methanol,DMFandDMSOandhasmoderatesolubilityinwater.
CASNumber
53-79-2
MolecularFormula
C22H29N7O5
MolecularWeight
471.5
MechanismofAction
Puromycinisnon-selective,inhibitingRNAbyblockingribosomaltranslation.
StorageConditions
-20°C