Bleomycinisacomplexof11glycopeptideantitumorantibioticsoriginallyisolatedfromStreptomycesverticillusin1972.ThedominantcomponentsofthecomplexarebleomycinA2andB2,whichtypicallyrepresent>90%ofthetotalweight.Bleomycinshavefoundclinicalapplicationinthetreatmentofarangeoftumors.
Bleomycinissolublein waterandmethanol,withmoderateethanolsolubility.
CASNumber
9041-93-4
MolecularFormula
C55H84N17O21S3(forA2)
MolecularWeight
1415.6(forA2)
MechanismofAction
BleomycinsactbyintercalationofDNAandRNA.Inthepresenceofoxygenandmetalions,notablycopperandiron,bleomycinsformapseudo-enzymethatinducesDNAcleavage.
StorageConditions
-20°C