Artesunateisananti-malarialdrugandhasbeenfoundtobeeffectiveagainstmultidrug-resistant
malaria.Artesunatehasalsobeenfoundtohaveanti-canceractivityagainstleukemiaandcoloncancercelllines.
CASNumber
88495-63-0
MolecularFormula
C19H28O8
MolecularWeight
384.42
MechanismofAction
ArtesunatecausesdoublestrandedbreaksinparasiteDNAwhichleadstoabuildupofintracellularreactiveoxygenspecies(ROS).
StorageConditions
≤30°C
Spectrum
ArtesunateisactiveagainstPlasmodiumfalciparumandP.vivax.
Form
Powder
Appearance
Whitecrystallinepowder
Source
Artemisiaannua
ImpurityProfile
Singleimpurity:Notmorethan0.5%
Totalimpurities:Notmorethan2.0%
pH
3.5-5.0
MeltingPoint
132°C-136°C
OpticalRotation
+4.5-+6.5
Assay
(HPLC,Ondriedbasis):98.0%-102.0%
LossonDrying
Notmorethan0.5%
ResidueOnIgnition
Notmorethan0.1%
HeavyMetals
Notmorethan20ppm