Form
Powder
Appearance
Yellowtoorangepowder
Source
StreptomycesHygroscopicus
MeltingPoint
201-203°C
Geldanamycinisabenzoquinoneanti-tumoragentwhichinteractswiththestressinducedchaperoneproteinHsp90(heatshockprotein90).GeldanamycinisinsolubleinaqueoussolutionbutsolubleinDMSOandmethanol.
30562-34-6
C29H40N2O9
560.64g/mol
GeldanamycinbindsspecificallytotheheatshockproteinHsp90andtoitsendoplasmicreticulumhomologueGP96,andthusinterfereswithconformationalmaturationofproteinsandthecellularstressresponse.Inaddition,itisapotentinhibitorofthenuclearhormonereceptorfamily.
-20°C,protectfromlight
2941.90.1050
Powder
Yellowtoorangepowder
StreptomycesHygroscopicus
201-203°C