Source
Camptothecaacuminata(plant)
ImpurityProfile
RRT1.32Impurity:Notmorethan0.7%TotalImpurities:Notmorethan1.0%
Assay
Notlessthan99.0%
LossonDrying
Notmorethan1.0%
ResidueOnIgnition
Notmorethan0.3%
7689-03-4
C20H16N2O4
348.352
CamptothecininhibitsDNAreligationinthecleavage/religationstepbybindingtoDNAtopoisomeraseI(topoI)andDNAwhichformsaDNAtopoisomeraseI-camptothecin-DNAcomplex.ThiscomplexcausesDNAdamageandleadstoapoptosis.
2-8°C
Camptothecaacuminata(plant)
RRT1.32Impurity:Notmorethan0.7%TotalImpurities:Notmorethan1.0%
Notlessthan99.0%
Notmorethan1.0%
Notmorethan0.3%