Norfloxacinisafirstgenerationsyntheticfluoroquinoloneantibioticandissparinglysolubleinaqueoussolutionat1mg/mL.
CASNumber
70458-96-7
MolecularFormula
C16H18FN3O3
MolecularWeight
319.33
MechanismofAction
NorfloxacinindirectlyinhibitsDNAgyrasebybindingtonearbyDNAsubstrate.DNAgyraseisanessentialDNAreplicationenzymewhichreducesDNAstrainduringactiveDNAreplication.NorfloxacinismostactiveinthepHrangebetween4.5and6.5.
StorageConditions
2-8°C
TariffCode
2933.59.3600
Spectrum
NorfloxacinisabroadspectrumantibioticcommonlyusedtotargetbacteriaresponsIBLeforurinarytractinfections.
Form
Powder
Appearance
Whitetolight-yellowcrystallinepowder
Source
Synthetic
ImpurityProfile
ImpurityA|7-Chloro-1-ethyl-6-fluoro-4-oxo-1,4-dihydroquinoline-3-carboxylicAcid||||ImpurityD|1-Ethyl-6-fluoro-7-(piperazin-1-yl)quinolin-4(1H)-one||||ImpurityG|1-Ethyl-6-fluoro-7-(4-formylpiperazin-1-yl)-4-oxo-1,4-dihydroquinoline-3-carboxylicAcid1-Ethyl-6-fluoro-7-(4-formylpiperazin-1-yl)-4-oxo-1,4-dihydro||||ImpurityF|ChloroanalogueofNorfoxacin||||
MeltingPoint
220-221°C
Assay
(OnDriedBasis):99.0-101.0%
LossonDrying
≤1.0%
