Norfloxacin is a first generation synthetic fluoroquinolone antibiotic and is sparingly soluble in aqueous solution at 1mg/mL.
CAS Number
70458-96-7
Molecular Formula
C16H18FN3O3
Molecular Weight
319.33
Mechanism of Action
Norfloxacin indirectly inhibits DNA gyrase by binding to nearby DNA substrate. DNA gyrase is an essential DNA replication enzyme which reduces DNA strain during active DNA replication. Norfloxacin is most active in the pH range between 4.5 and 6.5.
Storage Conditions
2-8°C
Tariff Code
2933.59.3600
Spectrum
Norfloxacin is a broad spectrum antibiotic commonly used to target bacteria responsible for urinary tract infections.
Form
Powder
Appearance
White to light-yellow crystalline powder
Source
Synthetic
Impurity Profile
Impurity A| 7-Chloro-1-ethyl-6-fluoro-4-oxo-1,4-dihydroquinoline-3-carboxylic Acid||||
Impurity D| 1-Ethyl-6-fluoro-7-(piperazin-1-yl)quinolin-4(1H)-one||||
Impurity G| 1-Ethyl-6-fluoro-7-(4-formylpiperazin-1-yl)-4-oxo-1,4-dihydroquinoline-3-carboxylic Acid 1-Ethyl-6-fluoro-7-(4-formylpiperazin-1-yl)-4-oxo-1,4-dihydro||||
Impurity F| Chloro analogue of Norfoxacin||||
Melting Point
220-221°C
Assay
(On Dried Basis): 99.0-101.0%
Loss on Drying
≤1.0%
