Form
Powder
Appearance
White or off-white powder
Source
Streptomyces Hygroscopicus
Melting Point
183-185ºC
Loss on Drying
≤0.2%
Rapamycin (sirolimus) is a macrolide immunosuppressive and anti-tumor drug. Rapamycin is essentially insoluble in water.
Chen et al. used rapamycin from TOKU-E to study the mammalian target of rapamycin. "AMPA receptor–mTOR activation is required for the antidepressant-like effects of sarcosine during the forced swim test in rats: insertion of AMPA receptor may play a role"
53123-88-9
C51H79NO13
914.17
Rapamycin complexes with FK-binding protein (FKBP12) and inhibits mTOR (FRAP, RAFT), a member of the phosphoinositide kinase-related kinase (PIKK) family.
-20°C
Powder
White or off-white powder
Streptomyces Hygroscopicus
183-185ºC
≤0.2%