Cyclosporin, USP is a mixture of cyclic oligopeptide immunosuppressant compounds routinely given to patients after receiving an organ transplant to prevent transplant rejection. Cyclosporin, USP contains mostly cyclosporin A (>98.0%) which has the most potent immunosuppressant activity of the cyclosporins and is highly metabolized by humans and animals after ingestion. The resulting metabolites (cyclosporin B, C, D, E, H, L, and others) have been found to have less potent immunosuppressant activity and are associated with higher nephrotoxicity when compared to cyclosporin A.

TOKU-E offers purified forms of cyclosporin A, B, C, D, E, H, and L.

CAS Number

59865-13-3

Molecular Formula

C₆₂H₁₁₁N₁₁O₁₂

Molecular Weight

1202.61

Mechanism of Action

Cyclosporin A (CsA) immunosuppressant activity stems from its ability to prevent T-cell activation by blocking specific cytokine transcription genes. After entering a T-cell, cyclosporin A (CsA) associates with ubiquitous cytosolic proteins called cyclophilins which aid in protein folding. Cyclosporin A (CsA) : cyclophilin complexes together bind calcineurin, (another cytosolic protein) effectively blocking the pathway to IL-2 gene transcription and nitric oxide synthesis by TNFα and interleukin 1α.

Storage Conditions

2-8 °C

Specifications: