OligomycinAisthedominantanalogueofaclassofmacrocycliclactonesisolatedfromselectedstrainsofStreptomycessp.OligomycinAexhibitsabroad
icalprofileincludingantifungal,antitumorandnematocidalactivities.
OligomycinAissolubleinethanol,methanol,DMForDMSO.Poorwatersolubility.
CASNumber
579-13-5
MolecularFormula
C45H74O11
MolecularWeight
791.1
MechanismofAction
OligomycinAisaninhibitorofmitochondrialF1F0-ATPase.Itinducesapoptosisinavarietyofcelltypes,makescellsmoresusceptIBLetocelldeath,andalsoleadstoaswitchinthedeathmodefromapoptosistonecrosis.
StorageConditions
-20°C