Oligomycin A is the dominant analogue of a class of macrocyclic lactones isolated from selected strains of Streptomyces sp. Oligomycin A exhibits a broad biological profile including antifungal, antitumor and nematocidal activities.
Oligomycin A is soluble in ethanol, methanol, DMF or DMSO. Poor water solubility.
CAS Number
579-13-5
Molecular Formula
C45H74O11
Molecular Weight
791.1
Mechanism of Action
Oligomycin A is an inhibitor of mitochondrial F1F0-ATPase. It induces apoptosis in a variety of cell types, makes cells more susceptible to cell death, and also leads to a switch in the death mode from apoptosis to necrosis.
Storage Conditions
-20°C