Erythromycin is a macrolide antibiotic with a target spectrum similar to penicillin.
TOKU-E offers three forms of erythromycin: erythromycin (E002), erythromycin estolate (E003), and erythromycin ethylsuccinate (E004). Erythromycin is sparingly soluble in aqueous solution (2 mg/mL). Erythromycin estolate and erythromycin ethylsuccinate are both freely soluble in organic solvents.
CAS Number
114-07-8
Molecular Formula
C37H67NO13
Molecular Weight
733.93
Mechanism of Action
Macrolide antibiotics inhibit bacterial growth by targeting the 50S ribosomal subunit preventing peptide bond formation and translocation during protein synthesis. Resistance to erythromycin is commonly attributed to mutations in 50S rRNA preventing erythromycin binding allowing the cell to synthesize proteins free of error.
Storage Conditions
<30°C
Tariff Code
2941.50.0000
Spectrum
Erythromycin is a broad spectrum antibiotic commonly targeting bacteria responsible for respiratory tract infections including Mycoplasma pneumoniae and Legionella pneumophila
Form
Powder
Appearance
White powder
Source
Biosynthetic: Saccharopolyspora erythraea (formerly Streptomyces erythraeus).
Impurity Profile
Erythromycin A||7540-22-9|C37H67NO13|733.93|
Erythromycin B| 12-deoxy erythromycin|527-75-3|C37H67NO12|717.9|
Erythromycin C| 3"-o-demethyl erythromycin A|1675-02-1|C36H65NO13|720.92|
Erythromycin D| 3"-o-demethyl-12-deoxy erythromycin A||C36H65NO12|703.45|
Impurity A| Erythromycin F|82230-93-1|C37H67NO14|749.46|
Impurity B| N-demethyl erythromycin A|992-62-1|C36H65NO13|719.91|
Impurity C| Erythromycin E|41451-91-6|C37H65NO14|747.91|
Impurity D| Anhydroerythromycin A|23893-13-2|C37H65NO12|715.91|
Impurity E| Erythromycin A enol ether|33396-29-1|C37H65NO12|715.91|
Water Content (Karl Fisher)
≤10.0%
Melting Point
135-140°C
Optical Rotation
-71° to -78°
Assay
(On Dried Basis): 85-100.5%
