Acycloguanosine (Acyclovir) is a synthetic purine nucleoside analog and is used as an antiviral medication for the treatment of herpes simplex virus (HSV), shingles, and chickenpox.
CAS Number
59277-89-3
Molecular Formula
C8H11N5O3
Molecular Weight
225.21
Mechanism of Action
Acycloguanosine is converted to acyclovir triphosphate (ACV-TP) by viral enzymes which inactivates HSV DNA polymerases.
Spectrum
Acycloguanosine targets most herpesvirus species including HSV-1, HSV-2, cytomegalovirus, Epstein-Barr virus (EBV), and Varicella zoster virus (VZV).
Appearance
White or almost white crystalline powder
Impurity Profile
TLC: Not more than 0.5%
HPLC, Guanine: Not more than 0.7%
Single Impurity: Not more than 0.5%
Total Impurities: Not more than 1.0%
Water Content (Karl Fisher)
Not more than 6.0%
Assay
(Anhydrous Basis): 98.5% - 101.0%
Sulfated Ash
Not more than 0.1%
Heavy Metals
Not more than 10ppm
