Cefotaxime sodium is a third generation cephalosporin antibiotic.

TOKU-E offers two forms of cefotaxime: cefotaxime sodium, USP (C011) and cefotaxime sodium, CulturePure® (C106). Both forms have are freely soluble in aqueous solution (50 mg/mL). Ultrapure cefotaxime is >99% pure cefotaxime and is free of E-cefotaxime, an otherwise present but toxic isoform.

CAS Number

64485-93-4

Molecular Formula

C₁₆H₁₆N₅NaO₇S₂

Molecular Weight

447.45

Mechanism of Action

Like β-lactams, cephalosporins interfere with PBP (penicillin binding protein) activity involved in the final phase of peptidoglycan synthesis. PBP’s are enzymes which catalyze a pentaglycine crosslink between alanine and lysine residues providing additional strength to the cell wall. Without a pentaglycine crosslink, the integrity of the cell wall is severely compromised and ultimately leads to cell lysis and death. Resistance to cephalosporins is commonly due to cells containing plasmid encoded β-lactamases. Cefotaxime sodium however, is largely resistant to β-lactamases.

Storage Conditions

-20°C

Tariff Code

2941.90.5000

Spectrum

Cefotaxime sodium has broad spectrum activity against a wide variety of gram positive and gram negative bacteria. However, unlike many cephalosporin antibiotics, cefotaxime sodium is not effective against Pseudomonas aeruginosa.

Specifications: