Form
Powder
Appearance
White or almost white powder
Impurity Profile
LD50 in mice (mg/kg): ≈15,000 orally; 700 s.c.; 110 i.v. (Di Marco, Bertazzoli).
pH
5.0-7.5
Melting Point
>200 °C
Optical Rotation
+50° to +55°
Paromomycin sulfate is a freely soluble (50 mg/mL) aminoglycoside antibacterial and antiparasitic drug.
1263-89-4
C23H45N5O14 · H2SO4
713.71 g/mol
Like many aminoglycosides, paromomycin targets the 16S rRNA of the 30S ribosomal subunit and prevents translocation and misreading of mRNA by stabilizing aminoacyl-tRNA in the acceptor (“A”) site.
2-8 °C
2941.90.1010
Paromomycin is a broad spectrum antibiotic targeting a wide range of gram positive and gram negative bacteria including Escherichia coli and Staphylococcus species.
Powder
White or almost white powder
LD50 in mice (mg/kg): ≈15,000 orally; 700 s.c.; 110 i.v. (Di Marco, Bertazzoli).
5.0-7.5
>200 °C
+50° to +55°