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Whiteoralmostwhitepowder
ImpurityProfile
LD50inmice(mg/kg):≈15,000orally;700s.c.;110i.v.(DiMarco,Bertazzoli).
pH
5.0-7.5
MeltingPoint
>200°C
OpticalRotation
+50°to+55°
Paromomycinsulfateisafreelysoluble(50mg/mL)aminoglycosideantibacterialandantiparasiticdrug.
1263-89-4
C23H45N5O14·H2SO4
713.71g/mol
Likemanyaminoglycosides,paromomycintargetsthe16SrRNAofthe30SribosomalsubunitandpreventstranslocationandmisreADIngofmRNAbystABIlizingaminoacyl-tRNAintheacceptor(“A”)site.
2-8°C
2941.90.1010
ParomomycinisabroadspectrumantibiotictargetingawiderangeofgrampositiveandgramnegativebacteriaincludingEscherichiacoliandStaphylococcusspecies.
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Whiteoralmostwhitepowder
LD50inmice(mg/kg):≈15,000orally;700s.c.;110i.v.(DiMarco,Bertazzoli).
5.0-7.5
>200°C
+50°to+55°