Siomycinisamacrocyclicantibioticwithpotentandselectiveantibacterialactivitydiscoveredin1969.Siomycinisapotentinhibitoroftheoncogenictranscriptionfactor,FoxM1.ThereducedtranscriptionactivityisreflectedinthedownregulationofproteinandmRNAlevelsofFoxM1andeffectsondownstreamgenes,Cdc25B,survivinandCENPB.Invitro,siomycininhibitsFoxM1-inducedcellgrowthonsoftagarandselectivelykillstransformedbutnotnormalcells.
Siomycinissoluble inDMFandDMSO.
CASNumber
12656-09-6
MolecularFormula
C71H81N19O18S5
MolecularWeight
1648.9
StorageConditions
-20°C
Specifications: