Salinomycin is a coccidiostat ionophore antibiotic.
TOKU-E offers two forms of salinomycin: salinomycin (S001) and salinomycin sodium (S002). Salinomycin is slightly soluble in methanol at 10 mg/mL. Salinomycin sodium is insoluble in water, freely soluble in acetone, and 200 mg/mL soluble in ethanol.
This product is considered a dangerous good. Quantities above 1 g may be subject to additional shipping fees. Please contact us for specific questions.
Fangyuan Xie et al. used salinomycin from TOKU-E to study its efficacy toward liver cancer cells when used in combination with chloroquine. Read more here: "Codelivery of salinomycin and chloroquine by liposomes enables synergistic antitumor activity in vitro."
CAS Number
55721-31-8
Molecular Formula
C42H69NaO11
Molecular Weight
772.98 (anhydrous basis)
Mechanism of Action
Salinomycin interacts with the gram positive cell membrane which decreases control of ion permeability. This effect allows ions (K+, Na+, Ca+, Mg2+) to accumulate inside the cell to toxic levels.
Storage Conditions
2-8°C
Tariff Code
2941.90.1050
Spectrum
Salinomycin targets primarily the gram positive cell wall to allow ion transport into the cell. Gram negative organisms are unaffected by salinomycin because of their additional outer membrane.
Form
Powder
Appearance
White crystalline powder
Source
Streptomyces albus
Impurity Profile
Arsenic: ≤0.0004%
Elaiophilin: ≤0.0032%
pH
6.5-8.5
Melting Point
140-142°C
Assay
(Dried Basis): ≥900u/mg
Loss on Drying
≤7.0%
Heavy Metals
Not more than 0.002%