Zotarolimusisasemi-syntheticmacrocycliclactonepreparedfromrapamycinbypreparationofthe42-triflateester,followedbydisplacementwithtetrazoleandpurificationofthetwoisomericproducts.Thisstructuralchangeaffordsalessbioavailableproduct,apreferredprofileforsomeapplications.Zotarolimusisextensivelycitedintheliteraturewithover200citations.
CASNumber
221877-54-9
MolecularFormula
C52H79N5O12
MolecularWeight
966.2
MechanismofAction
Zotarolimusbindstoareceptorprotein(FKBP12).ThecomplexthenbindstomTORpreventingitfrominteractingwithtargetproteins.