Monactin is a member of the macrotetrolide complex produced by a range of Streptomyces species. Monactin has not previously been available for intensive investigation. Early literature reported that the related dinactin is a monovalent cation ionophore with high selectivity for ammonium and potassium. Monactin inhibits T-cell proliferation induced by IL-2 and cytokine production at nanomolar levels for IL-2, IL-4, IL-5 and IFN-
γ.
Monactin is soluble in ethanol, methanol, DMF or DMSO. Poor water solubility.
CAS Number
7182-54-9
Molecular Formula
C41H66O12
Molecular Weight
751.0
Storage Conditions
-20°C
Specifications:
Appearance
Colourless Film