7-OxostaurosporineistheoxidisedandhighlyfluorescentanalogueofUCN-01andUCN-02.7-OxostaurosporineisapotentinhibitorofproteinkinaseCandformationofcellularblebsinducedbyphorbols.7-Oxostaurosporine possessescomparableactivityagainsttumorcellslinestoUCN-01.DespiteitscloserelationshiptoUCN-01andstaurosporine,limitedaccesstothemetabolitehasrestrictedamorecompleteinvestigationofitsproperties.
7-Oxostaurosporineissolubleinethanol,methanol,DMForDMSO.Poorwatersolubility.
CASNumber
141196-69-2
MolecularFormula
C28H24N4O4
MolecularWeight
480.5
MechanismofAction
7-OxostaurosporineinhibitsthecellcycleattheG2stagewiththeaccumulationof4CDNAcells
StorageConditions
-20°C