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RecentresearchshowsthatterreinreducesmelaninsynthesisbyreducingtyrosinaseproductionviaERKactivation,followedbyMITFdown-regulation.TerreinalsoreduceshumankeratinocyteproliferationbyinhibitingERKandbydecreasingtheexpressionofcyclinB1andCdc2complex.
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